The Tuolumne River flows for 149 miles (240 km) through Central California, from the high Sierra Nevada to join the San Joaquin River in the Central Valley. Originating at over 8,000 feet (2,400 m) above sea level in Yosemite National Park, the Tuolumne drains a rugged watershed of 1,958 square miles (5,070 km2), carving a series of canyons through the western slope of the Sierra. While the upper Tuolumne is a fast-flowing mountain stream, the lower river crosses a broad, fertile and extensively cultivated alluvial plain. Like most other central California rivers, the Tuolumne is dammed multiple times for irrigation and the generation of hydroelectricity.

The Sierra Nevada is a mountain range in the Western United States, between the Central Valley of California and the Great Basin. The vast majority of the range lies in the state of California, although the Carson Range spur lies primarily in Nevada. The Sierra Nevada is part of the American Cordillera, an almost continuous chain of mountain ranges that forms the western "backbone" of the Americas.