The Tweed River is a river situated in the Northern Rivers region of New South Wales, Australia. From the middle reaches of its course, the state boundary between New South Wales and Queensland is located approximately 10 kilometres (6.2 mi) north.

Northern Rivers is the most northeasterly region of the Australian state of New South Wales, located between 590 and 820 kilometres north of the state capital, Sydney, and encompasses the catchments and fertile valleys of the Clarence, Richmond, and Tweed rivers. It extends from Tweed Heads in the north to the southern extent of the Clarence river catchment which lies between Grafton and Coffs Harbour, and includes the main towns of Tweed Heads, Byron Bay, Ballina, Kyogle, Lismore, Casino and Grafton. At its most northern point, the region is 102 kilometres (63 mi) south-southeast of the Queensland capital, Brisbane.