Tyrone is a borough in Blair County, Pennsylvania, United States, located 15 miles (24 km) northeast of Altoona, on the Little Juniata River. Tyrone was of considerable commercial importance in the twentieth century. It was an outlet for the Clearfield coal fields and was noted for manufacturing paper products. There were planing mills and chemical and candy factories. In 1900, 5,847 people lived here; in 1910, 7,176; and in 1940, 8,845 people resided here. The population was 5,477 at the 2010 census. It is part of the Altoona, PA Metropolitan Statistical Area. It was named after County Tyrone in Ireland.

Blair County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 122,822. Its county seat is Hollidaysburg, and its largest city is Altoona. The county was created on February 26, 1846, from parts of Huntingdon and Bedford counties. The county is part of the Southwest Pennsylvania region of the state.