U.S. Highway 10 (US 10) is a major divided highway for almost all of its length in the U.S. state of Minnesota. The route runs through the central portion of the state, following generally the alignment of the former Northern Pacific Railway and connects the cities of Moorhead, Detroit Lakes, Wadena, Little Falls, St. Cloud, Anoka, Saint Paul, and Cottage Grove. US 10 within Minnesota is 275 miles (443 km) in length.

Moorhead is a city in and county seat of Clay County, Minnesota, United States, on the banks of the Red River of the North. Located in the Red River Valley, an extremely fertile and active agricultural region, Moorhead is also home to several corporations and manufacturing industries. Across the river from Fargo, North Dakota, Moorhead helps form the core of the Fargo–Moorhead ND-MN Metropolitan Area. The population was 44,505 at the 2020 census.