US Highway 12 (US 12) is an east–west United States Numbered Highway that runs from Aberdeen, Washington, to Detroit, Michigan. In Michigan, it runs for 210 miles (340 km) between New Buffalo and Detroit as a state trunkline highway and Pure Michigan Byway. On its western end, the highway is mostly a two-lane road that runs through the southern tier of counties roughly parallel to the Indiana state line. It forms part of the Niles Bypass, a four-lane expressway south of Niles in the southwestern part of the state, and it runs concurrently with the Interstate 94 (I-94) freeway around the south side of Ypsilanti in southeastern Michigan. In between Coldwater and the Ann Arbor area, the highway angles northeasterly and passes Michigan International Speedway. East of Ypsilanti, US 12 follows a divided highway routing on Michigan Avenue into Detroit, where it terminates at an intersection with Cass Avenue.

New Buffalo is a city in Berrien County in the U.S. state of Michigan. The population was 1,708 during the 2020 census.