U.S. Route 180 is an east–west United States highway. Like many three-digit routes, US 180 no longer meets its "parent", US 80. US 80 was decommissioned west of Mesquite, Texas, and was replaced in Texas by Interstate 20 and Interstate 10 resulting in U.S. 180 being 57 miles longer than U.S. 80. The highway's eastern terminus is in Hudson Oaks, Texas, at an intersection with Interstate 20. Its western terminus is unclear. Signage at an intersection with State Route 64 in Valle, Arizona 40 miles (64 km) northwest of Flagstaff indicates that the route starts at SR 64, which is consistent with the AASHTO U.S. Highway logs. However, many maps continue the US 180 designation to the south rim of the Grand Canyon at Grand Canyon Village. Signage at the SR 64 intersection as of 2021 indicated that US 180 continues north concurrent with the route. However, no signage along the route exists past this intersection until SR 64 turns east towards Cameron, Arizona. At this intersection, signage makes no mention of US 180 nor is there any mention at the terminus of SR 64 at US 89.

Interstate 20 (I‑20) is a major east–west Interstate Highway in the Southern United States. I-20 runs 1,539 miles (2,477 km) beginning at an interchange with I-10 in Reeves County, Texas, and ending at an interchange with I-95 in Florence, South Carolina. Between Texas and South Carolina, I-20 runs through northern Louisiana, Mississippi, Alabama, and Georgia. The major cities that I-20 connects to include Dallas-Fort Worth, Texas; Shreveport, Louisiana; Jackson, Mississippi; Birmingham, Alabama; Atlanta, Georgia; and Columbia, South Carolina.