U.S. Route 287 (US 287) is a north–south United States highway. At 1,791 miles (2,882 km) long, it is the second longest three-digit U.S. Route, behind US 281. It serves as the major truck route between Dallas-Fort Worth and Amarillo, Texas, and between Fort Collins, Colorado, and Laramie, Wyoming. The highway is broken into two segments by Yellowstone National Park, where unnumbered park roads serve as a connector.

U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route.