U.S. Route 421 is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee, Virginia, Kentucky, and Indiana. The highway runs for 941 miles (1,514 km) from Fort Fisher, North Carolina, to US 20 in Michigan City, Indiana. Along its routing, US 421 serves several cities including Wilmington, North Carolina; Greensboro, North Carolina; Bristol, Tennessee and Virginia; Lexington, Kentucky; and Indianapolis, Indiana. US 421 is a spur route of US 21, which it meets west of Yadkinville, North Carolina.
US 421 south near the Red White and Blue Road (exit 276) in eastern Wilkes County, July 2007
US 421 near Bristol in June 2006
US 421 in Michigan City, just north of I-94
Beginning of US 421 near Fort Fisher State Recreation Area
Bristol is an independent city in the Commonwealth of Virginia. As of the 2020 census, the population was 17,219. It is the twin city of Bristol, Tennessee, just across the state line, which runs down the middle of its main street, State Street. It is surrounded on three sides by Washington County, Virginia, which is combined with the city for statistical purposes. It is a principal city in the Kingsport–Bristol metropolitan area, which had a population of 307,614 in 2020. The metro area is a component of the larger Tri-Cities region of Tennessee and Virginia, with a population of 508,260 in 2020.
State Street in downtown Bristol, Tennessee (left) and Bristol, Virginia (right)
Bristol Virginia-Tennessee Slogan Sign
State Street separates Virginia (left) and Tennessee (right).
Double yellow line on State Street, separating Virginia from Tennessee with a bronze marker embedded in pavement.