U.S. Route 460 (US 460) in Virginia runs west-east through the southern part of the Commonwealth. The road has two separate pieces in Virginia, joined by a relatively short section in West Virginia. Most of US 460 is a four-lane divided highway and is a major artery in the southern third of the state. From Petersburg to Suffolk, US 460 is a four-lane non-divided highway. It is a popular alternative to Interstate 64 (I-64) when going from Richmond and other points in central Virginia to the Currituck Sound and Outer Banks of North Carolina, avoiding the congestion and tunnels of the more northerly I-64 corridor. The road passes through several small towns that built up at stops along the railroad line.

Petersburg is an independent city in the Commonwealth of Virginia in the United States. As of the 2020 census, the population was 33,458 with a majority black American. The Bureau of Economic Analysis combines Petersburg with Dinwiddie County for statistical purposes. The city is 21 miles (34 km) south of the commonwealth (state) capital city of Richmond.