U.S. Route 67 (US 67) is a component of the United States Numbered Highway System that connects Presidio, Texas, to Sabula, Iowa. In Illinois, it serves the western region of the state known as Forgottonia, named for the lack of regional transportation and infrastructure projects. The highway begins its path through the state by crossing the Clark Bridge over the Mississippi River from Missouri at Alton and heads northward through Jerseyville and Jacksonville before it crosses the Illinois River at Beardstown. The northern half of the route serves Macomb and Monmouth before it enters the Quad Cities. It leaves the state at Rock Island by crossing the Rock Island Centennial Bridge over the Mississippi River into Davenport, Iowa.

Forgottonia, also spelled Forgotonia, is the name given to a 16-county region in Western Illinois in the late 1960s and early 1970s. This geographic region forms the distinctive western bulge of Illinois that is roughly equivalent to "The Tract", the Illinois portion of the Military Tract of 1812, along and west of the Fourth Principal Meridian. Since this wedge-shaped region lies between the Illinois and Mississippi rivers, it has historically been isolated from the eastern portion of Central Illinois.