U.S. Route 6 (US 6) is a transcontinental United States Numbered Highway, stretching from Bishop, California, in the west to Provincetown, Massachusetts, in the east. The California portion of US 6 lies in the eastern portion of the state from Bishop in the Owens Valley north to the Nevada state line in Mineral County. Prior to the 1964 state highway renumbering, US 6 extended to the Pacific Ocean in Long Beach, California, as part of the historic auto trail named the Grand Army of the Republic Highway.

Bishop is a city in California, United States. It is the largest populated place and only incorporated city in Inyo County. Bishop is located near the northern end of the Owens Valley at an elevation of 4,150 feet (1,260 m). The city was named after Bishop Creek, flowing out of the Sierra Nevada; the creek was named after Samuel Addison Bishop, a settler in the Owens Valley. Bishop is a commercial and residential center, while many vacation destinations and tourist attractions in the Sierra Nevada are located nearby.