U.S. Route 71 (US 71) is a major north–south U.S. Highway that runs from Louisiana to Canada. US 71 enters Missouri from Arkansas in the town of Jane. US 71 serves the cities of Joplin, Kansas City and St. Joseph. At noon on December 12, 2012, the section of US 71 between Pineville, Missouri and I-435 in south Kansas City was also designated as a northern extension of Interstate 49 (I-49).

Joplin is a city in Jasper and Newton counties in the southwestern corner of the U.S. state of Missouri. The bulk of the city is in Jasper County, while the southern portion is in Newton County. Joplin is the largest city located within both Jasper and Newton Counties – even though it is not the county seat of either county. With a population of 51,762 as of the 2020 census, Joplin is the 13th most-populous city in the state. The city covers an area of 35.69 square miles (92.41 km2) on the outer edge of the Ozark Mountains. Joplin is the main hub of the three-county Joplin-Miami, Missouri-Oklahoma Metro area, which is home to 210,077 people making it the 5th largest metropolitan area in Missouri. In May 2011, a violent EF5 tornado killed more than 150 people and destroyed one-third of the city.