USS John Paul Jones (DDG-53) is the third Arleigh Burke-class guided missile destroyer in the United States Navy and the first ship of the class homeported on the west coast. She is the fifth ship named after American Revolutionary War naval captain John Paul Jones and the second to carry his first name. She was built at Bath Iron Works in Bath, Maine. The ship is part of Destroyer Squadron 9 of Carrier Strike Group 11, which is headed by the nuclear-powered aircraft carrier USS Nimitz (CVN-68).

A guided-missile destroyer (DDG) is a destroyer whose primary armament is guided missiles so they can provide anti-aircraft warfare screening for the fleet. The NATO standard designation for these vessels is DDG, while destroyers which have a primary gun armament or a small number of anti-aircraft missiles sufficient only for point-defense are designated DD. Nations vary in their use of destroyer D designation in their hull pennant numbering, either prefixing or dropping it altogether.