The deputy secretary of state of the United States is the principal deputy to the secretary of state. As of February 2024, the position is held by Kurt M. Campbell, who is serving under United States Secretary of State Antony Blinken. If the secretary of state resigns or dies, the deputy secretary of state becomes acting secretary of state until the president nominates and the Senate confirms a replacement. The position was created in 1972. Prior to July 13, 1972, the under secretary of state had been the second ranking officer of the Department of State.

The United States secretary of state (SecState) is a member of the executive branch of the federal government and the head of the Department of State. The office holder is the second-highest-ranking member of the president's Cabinet, after the vice president, and ranks fourth in the presidential line of succession; first amongst cabinet secretaries.