The University of Hawaiʻi at Mānoa is a public land-grant research university in Mānoa, a neighborhood of Honolulu, Hawaii. It is the flagship campus of the University of Hawaiʻi system and houses the main offices of the system. Most of the campus occupies the eastern half of the mouth of Mānoa Valley, with the John A. Burns School of Medicine located adjacent to the Kakaʻako Waterfront Park.

Honolulu is the capital and most populous city of the U.S. state of Hawaii, which is in the Pacific Ocean. An unincorporated city, it is the county seat of the consolidated City and County of Honolulu, situated along the southeast coast of the island of Oʻahu, and is the westernmost and southernmost major U.S. city. Honolulu is Hawaii's main gateway to the world. It is also a major hub for business, finance, hospitality, and military defense in both the state and Oceania. The city is characterized by a mix of various Asian, Western, and Pacific cultures, reflected in its diverse demography, cuisine, and traditions.