The University of San Francisco (USF) is a private Jesuit university in San Francisco, California. The university's main campus is located on a 55-acre (22 ha) setting between the Golden Gate Bridge and Golden Gate Park. The main campus is nicknamed "The Hilltop" and is split into two sections within a block of each other. Part of the main campus is located on Lone Mountain, one of San Francisco's major geographical features. Its close historical ties with the City and County of San Francisco are reflected in the university's traditional motto, Pro Urbe et Universitate.

San Francisco, officially the City and County of San Francisco, is a commercial, financial, and cultural center in Northern California. With a population of 808,437 residents as of 2022, San Francisco is the fourth most populous city in the U.S. state of California. The city covers a land area of 46.9 square miles at the end of the San Francisco Peninsula, making it the second-most densely populated large U.S. city after New York City and the fifth-most densely populated U.S. county, behind only four New York City boroughs. Among the 92 U.S. cities proper with over 250,000 residents, San Francisco is ranked first by per capita income and sixth by aggregate income as of 2022.