The University of Tennessee System is a system of public universities in the U.S. state of Tennessee. It is one of two public university systems, the other being the Tennessee Board of Regents (TBR). It consists of four primary campuses in Knoxville, Chattanooga, Pulaski and Martin; a health sciences campus in Memphis; a research institute in Tullahoma; and various extensions throughout the state.

A university system is a set of multiple affiliated universities and colleges that are usually geographically distributed. Typically, all member universities in a university system share a common component among all of their various names. Usually, all member universities of a university system are governed by a system-wide governing body, such as a board of trustees or a board of regents. In the United States, many states have one or two state university systems under which many of their publicly funded universities are aligned, both in name and in governance. Additionally, for-profit universities, such as DeVry University, often have multiple campuses which share the same name; these may be, but are not always, described as a university system.