Uzbekistan competed at the 2012 Summer Olympics in London, from July 27 to August 12, 2012. This was the nation's fifth consecutive appearance at the Olympics. The National Olympic Committee of the Republic of Uzbekistan sent the nation's smallest delegation to the Games in the post-Soviet era. A total of 54 athletes, 36 men and 18 women, competed in 13 sports. There was only a single competitor in fencing, rhythmic and trampoline gymnastics, shooting and tennis.

The 2012 Summer Olympics, officially known as the Games of the XXX Olympiad, was a summer multi-sport event held in London, the capital of the United Kingdom, from 27 July to 12 August. A total of 10,768 athletes from 204 nations participated in 302 events in 26 sports across 39 different disciplines.