Van Buren County is a county located in the U.S. state of Tennessee. As of the 2020 census, the population was 6,168, making it the second-least populous county in Tennessee. Its county seat is Spencer.

Spencer is a town in Van Buren County, Tennessee, United States. The population was 1,683 as of the 2010 census. It is the county seat of Van Buren County. It is home to Fall Creek Falls State Park.