Van Nuys is a neighborhood in the central San Fernando Valley region of Los Angeles, California. Home to Van Nuys Airport and the Valley Municipal Building, it is the most populous neighborhood in the San Fernando Valley.

Van Nuys Airport is a public airport in the Van Nuys neighborhood of the City of Los Angeles. The airport is operated by Los Angeles World Airports (LAWA), a branch of the Los Angeles city government, which also operates Los Angeles International Airport (LAX). Van Nuys is one of the busiest general aviation airports in the world, with the airport's two parallel runways averaging over 230,000 takeoffs and landings annually. However, as of 2022, no commercial air service operates to or from Van Nuys.