Victorio's War, or the Victorio Campaign, was an armed conflict between the Apache followers of Chief Victorio, the United States, and Mexico beginning in September 1879. Faced with arrest and forcible relocation from his homeland in New Mexico to San Carlos Indian Reservation in southeastern Arizona, Victorio led a guerrilla war across southern New Mexico, west Texas and northern Mexico. Victorio fought many battles and skirmishes with the United States Army and raided several settlements until the Mexican Army killed him and most of his warriors in October 1880 in the Battle of Tres Castillos. After Victorio's death, his lieutenant Nana led a raid in 1881.

The Apache are several Southern Athabaskan language–speaking peoples of the Southwest, the Southern Plains and Northern Mexico. They are linguistically related to the Navajo. They migrated from the Athabascan homelands in the north into the Southwest between 1000 and 1500 CE.