Viru Viru International Airport in Santa Cruz de la Sierra is Bolivia's largest international airport. Viru Viru handles domestic, regional, and international flights from Bolivia, North America, South America and Europe and serves as a focus city for Bolivia's biggest airline Boliviana de Aviación. The airport is able to handle large aircraft such as the Boeing 747-400, Airbus A340-600 and Boeing 777-300ER.

Santa Cruz de la Sierra, commonly known as Santa Cruz, is the largest city in Bolivia and the capital of the Santa Cruz department.