The W80 is a low to intermediate yield two-stage thermonuclear warhead deployed by the U.S. enduring stockpile with a variable yield ("dial-a-yield") of 5 or 150 kilotonnes of TNT.

A thermonuclear weapon, fusion weapon or hydrogen bomb (H bomb) is a second-generation nuclear weapon design. Its greater sophistication affords it vastly greater destructive power than first-generation nuclear bombs, a more compact size, a lower mass, or a combination of these benefits. Characteristics of nuclear fusion reactions make possible the use of non-fissile depleted uranium as the weapon's main fuel, thus allowing more efficient use of scarce fissile material such as uranium-235 or plutonium-239. The first full-scale thermonuclear test was carried out by the United States in 1952 and the concept has since been employed by most of the world's nuclear powers in the design of their weapons.