Walla Walla Valley is an American Viticultural Area (AVA) located within Washington state and extending partly into the northeastern corner of Oregon. The wine region is entirely included within the larger Columbia Valley AVA. In addition to grapes, the area produces sweet onions, wheat and strawberries After the Yakima Valley AVA, the Walla Walla AVA has the second highest concentration of vineyards and wineries in Washington State. Walla Walla hosts about 140 wineries. The area was recognized on March 7, 1984 by the Bureau of Alcohol, Tobacco and Firearms (ATF), Treasury after reviewing the petition submitted by Mr. Richard L Small, President of the Walla Walla Valley Winegrowers Association, for the establishment of a viticultural area in southeast Washington and northeast Oregon, east of Lake Wallula, to be known as "Walls Walls Valley." At the time, Walla Walla Valley viticultural area was approximately 178,560 acres (279 sq mi) with two bonded wineries and about 60 acres (24 ha) from several vineyards.

An American Viticultural Area (AVA) is a designated wine grape-growing region in the United States, providing an official appellation for the mutual benefit of wineries and consumers. Winemakers frequently want their consumers to know about the geographic pedigree of their wines, as wines from a particular area can possess distinctive characteristics. Consumers often seek out wines from specific AVAs, and certain wines of particular pedigrees can claim premium prices and loyal customers. If a wine is labeled with an AVA, at least 85% of the grapes that make up the wine must have been grown in the AVA, and the wine must be fully finished within the state where the AVA is located.