The Warsaw Ghetto was the largest of the Nazi ghettos during World War II and the Holocaust. It was established in November 1940 by the German authorities within the new General Government territory of occupied Poland. At its height, as many as 460,000 Jews were imprisoned there, in an area of 3.4 km2 (1.3 sq mi), with an average of 9.2 persons per room, barely subsisting on meager food rations. Jews were deported from the Warsaw Ghetto to Nazi concentration camps and mass-killing centers. In the summer of 1942, at least 254,000 ghetto residents were sent to the Treblinka extermination camp during Großaktion Warschau under the guise of "resettlement in the East" over the course of the summer. The ghetto was demolished by the Germans in May 1943 after the Warsaw Ghetto Uprising had temporarily halted the deportations. The total death toll among the prisoners of the ghetto is estimated to be at least 300,000 killed by bullet or gas, combined with 92,000 victims of starvation and related diseases, the Warsaw Ghetto Uprising, and the casualties of the final destruction of the ghetto.

Beginning with the invasion of Poland during World War II, the Nazi regime set up ghettos across German-occupied Eastern Europe in order to segregate and confine Jews, and sometimes Romani people, into small sections of towns and cities furthering their exploitation. In German documents, and signage at ghetto entrances, the Nazis usually referred to them as Jüdischer Wohnbezirk or Wohngebiet der Juden, both of which translate as the Jewish Quarter. There were several distinct types including open ghettos, closed ghettos, work, transit, and destruction ghettos, as defined by the Holocaust historians. In a number of cases, they were the place of Jewish underground resistance against the German occupation, known collectively as the ghetto uprisings.