Wayne County is a county located in the Ozark foothills in the U.S. state of Missouri. As of the 2020 census, the population was 10,974. The county seat is Greenville. The county was officially organized on December 11, 1818, and is named after General "Mad" Anthony Wayne, who served in the American Revolution. As of August 28, 2023, Wayne County is designated the UFO Capital of Missouri, along with the city of Piedmont.

Piedmont is a city in northwestern Wayne County in Southeast Missouri, United States. Its population was 1,897 at the 2020 census. Part of the Ozark Foothills Region, it is at the convergence of State Highways 34 and 49. Piedmont, transliterated as "foot of the mountain," is named for its position at the foot of Clark Mountain, a 1424-foot summit approximately two miles north of the town.