Wharfedale is the valley of the upper parts of the River Wharfe and one of the Yorkshire Dales. It is situated in North Yorkshire, and the cities of Leeds and Bradford in West Yorkshire. It is the upper valley of the River Wharfe. Towns and villages in Wharfedale include Buckden, Kettlewell, Conistone, Grassington, Hebden, Bolton Abbey, Addingham, Ilkley, Burley-in-Wharfedale, Otley, Pool-in-Wharfedale, Arthington, Collingham and Wetherby. Beyond Wetherby, the valley opens out and becomes part of the Vale of York.

The River Wharfe is a river in Yorkshire, England originating within the Yorkshire Dales National Park. For much of its middle course it is the county boundary between West Yorkshire and North Yorkshire. Its valley is known as Wharfedale.