Woods Hole is a census-designated place in the town of Falmouth in Barnstable County, Massachusetts, United States. It lies at the extreme southwestern corner of Cape Cod, near Martha's Vineyard and the Elizabeth Islands. The population was 781 at the 2010 census. The eminent Hungarian born biochemist and Nobel prize laureate, Albert Imre Szent-Györgyi de Nagyrápolt died here in 1986.

Falmouth is a town in Barnstable County, Massachusetts, United States. The population was 32,517 at the 2020 census, making Falmouth the second-largest municipality on Cape Cod after Barnstable. The terminal for the Steamship Authority ferries to Martha's Vineyard is located in the village of Woods Hole in Falmouth. Woods Hole also contains several scientific organizations such as the Woods Hole Oceanographic Institution (WHOI), the Marine Biological Laboratory (MBL), the Woodwell Climate Research Center, NOAA's Woods Hole Science Aquarium, and the scientific institutions' various museums.