Álvar Núñez Cabeza de Vaca was a Spanish explorer of the New World, and one of four survivors of the 1527 Narváez expedition. During eight years of traveling across what is now the US Southwest, he became a trader and faith healer to various Native American tribes before reconnecting with Spanish civilization in Mexico in 1536. After returning to Spain in 1537, he wrote an account, first published in 1542 as La relación y comentarios, which in later editions was retitled Naufragios y comentarios. Cabeza de Vaca is sometimes considered a proto-anthropologist for his detailed accounts of the many tribes of Native Americans that he encountered.

The Narváez expedition was a Spanish expedition started in 1527 that was intended to explore Florida and establish colonial settlements. The expedition was initially led by Pánfilo de Narváez, who died in 1528. Many more people died as the expedition traveled west along the explored Gulf Coast of the present-day United States and into the American southwest. Only four of the expedition's original members survived, reaching Mexico City in 1536. These survivors were the first known non-Native Americans to see the Mississippi River, and to cross the Gulf of Mexico and Texas.