České Budějovice District is a district in the South Bohemian Region of the Czech Republic. Its capital is the city of České Budějovice.

The South Bohemian Region is an administrative unit (kraj) of the Czech Republic, located mostly in the southern part of its historical land of Bohemia, with a small part in southwestern Moravia. The western part of the South Bohemian Region is former Prácheňsko, a huge archaic region with distinctive features with its capital, Písek. In 2011, there were 624 municipalities in the region, whereof 54 had a status of a town.