České Budějovice railway station is a mainline railway station and marshalling yard in České Budějovice in the Czech Republic. It is located at the junction of an international corridor leading from Prague south to Linz in Austria with several domestic lines. The Neo-Renaissance station building, completed in 1908, is located on Nádražní street, a short walk east of the old town. Most passenger services are operated by Czech Railways but some are operated by Arriva.

České Budějovice is a city in the South Bohemian Region of the Czech Republic. It has about 96,000 inhabitants. The city is located in the valley of the Vltava River, at its confluence with the Malše.