The .22 Winchester Magnum Rimfire, also known as the .22 WMR, .22 Magnum, .22 WMRF, .22 MRF, or .22 Mag, is a rimfire cartridge. Originally loaded with a bullet weight of 40 grains (2.6 g) delivering velocities in the 2,000 feet per second (610 m/s) range from a rifle barrel, .22 WMR is now loaded with bullet weights ranging from 50 grains (3.2 g) at 1,530 feet per second (470 m/s) to 30 grains (1.9 g) at 2,200 feet per second (670 m/s).

A rim-fire is a type of metallic cartridge used in firearms where the primer is located within a hollow circumferential rim protruding from the base of its casing. When fired, the gun's firing pin will strike and crush the rim against the edge of the barrel breech, sparking the primer compound within the rim, and in turn ignite the propellant within the case. Invented in 1845 by Louis-Nicolas Flobert, the first rimfire metallic cartridge was the .22 BB Cap cartridge, which consisted of a percussion cap with a bullet attached to the top. While many other different cartridge priming methods have been tried since the early 19th century, such as teat-fire and pinfire, only small caliber rimfire cartridges have survived to the present day with regular use. The .22 Long Rifle rimfire cartridge, introduced in 1887, is by far the most common ammunition found in the world today in terms of units manufactured and sold.