The .257 Weatherby Magnum is a .257 caliber (6.53 mm) belted bottlenecked cartridge. It is one of the original standard length magnums developed by shortening the .375 H&H Magnum case to approx. 2.5 in (64 mm). Of the cartridges developed by Roy Weatherby, the .257 Weatherby Magnum was known to have been his favorite, and the cartridge currently ranks third in Weatherby cartridge sales, after the .30-378 Weatherby Magnum and the .300 Weatherby Magnum.

Weatherby, Inc. is an American gun manufacturer founded in 1945 by Roy Weatherby. The company is best known for its high-powered magnum cartridges, such as the .257 Weatherby Magnum, .270 Weatherby Magnum, .300 Weatherby Magnum, .340 Weatherby Magnum and the .460 Weatherby Magnum. The company's headquarters is in Sheridan, Wyoming.