The .350 Remington Magnum was introduced in 1965 by Remington Arms Company for the Model 600 rifle. It was later offered in the Model 660 and Model 700 rifles but was discontinued as a regular factory chambering in 1974 after a poor sales record. Remington has also offered the Model Seven MS from their Custom Shop and a limited edition 700 Classic in recent years chambered in .350 Remington Magnum. Remington began chambering the round in the new Model 673 Guide Rifle in 2002. This caliber was also sold as a chambered size configuration in a line of long range shooting and competition handguns, the Remington XP-100.

The Remington XP-100 is a bolt-action pistol produced by Remington Arms from 1963 to 1998. The XP-100 was one of the first handguns designed for long-range shooting and introduced the .221 Fireball and 6×45mm. The XP-100 was noted for its accuracy and is still viewed as competitive today in the sport of handgun varminting, which it helped create, as well as in metallic silhouette shooting.