The .500 Bushwhacker is a .50 caliber semi-rimmed revolver cartridge developed by TII Armory for the Magnum Research BFR revolvers. It is currently the most powerful revolver cartridge in the world, offering a similar level of ballistic performance to African stopping rifles, such as the .416 Rigby and .470 Nitro Express. Given comparable barrel lengths, it is nearly twice as powerful as the .500 S&W Magnum. A 10-inch barrel revolver chambered in the cartridge is capable of penetrating 96-inches of 10% Clear Ballistics gel.

The .500 S&W Magnum or 12.7×41mmSR is a .50 caliber semi-rimmed revolver cartridge developed by Cor-Bon in partnership with the Smith & Wesson "X-Gun" engineering team for use in the Smith & Wesson Model 500 X-frame revolver and introduced in February 2003 at the SHOT Show. From its inception, it was intended to be the most powerful handgun cartridge to date, with the capacity to harvest all North American game species. While more powerful handgun cartridges, such as the .500 Bushwhacker, have emerged since, they are only available in custom firearms, and the .500 S&W remains the most powerful production handgun cartridge.