The .500 Nitro Express is a rifle cartridge designed for hunting large and dangerous game animals in Africa and India. This cartridge was primarily designed for use in double rifles though various single shots were produced on the Farquarson action and at least one major company (Heym) produced it in bolt-action configuration. It was commonly available in two lengths: a 3.00 in (76 mm) and a 3.25 in (83 mm) version.

The .460 Weatherby Magnum is a belted, bottlenecked rifle cartridge, developed by Roy Weatherby in 1957. The cartridge is based on the .378 Weatherby Magnum necked up to accept the .458-inch (11.6 mm) bullet. The original .378 Weatherby Magnum parent case was inspired by the .416 Rigby. The .460 Weatherby Magnum was designed as an African dangerous game rifle cartridge for the hunting of heavy, thick skinned dangerous game.