The .50 Action Express (AE) (12.7×33mmRB) is a large-caliber handgun cartridge, best known for its usage in the Desert Eagle. Developed in 1988 by American Evan Whildin of Action Arms, the .50 AE is one of the most powerful pistol cartridges in production.

In guns, particularly firearms, but not artillery, where a different definition may apply, caliber is the specified nominal internal diameter of the gun barrel bore – regardless of how or where the bore is measured and whether the finished bore matches that specification. It is measured in inches or in millimeters. In the United States it is expressed in hundredths of an inch; in the United Kingdom in thousandths; and elsewhere in millimeters. For example, a US "45 caliber" firearm has a barrel diameter of roughly 0.45 inches (11.43mm). Barrel diameters can also be expressed using metric dimensions. For example, a "9 mm pistol" has a barrel diameter of about 9 millimeters. Since metric and US customary units do not convert evenly at this scale, metric conversions of caliber measured in decimal inches are typically approximations of the precise specifications in non-metric units, and vice versa.