100 Bullets is an American comic book published by DC Comics under its Vertigo imprint. Written by Brian Azzarello and illustrated by Eduardo Risso, the comic book ran for 100 issues and won the Eisner Award and Harvey Award.

Vertigo Comics was an imprint of American comic book publisher DC Comics started by editor Karen Berger in 1993. Vertigo's purpose was to publish comics with adult content, such as nudity, drug use, profanity, and graphic violence, that did not fit the restrictions of DC's main line, thus allowing more creative freedom. Its titles consisted of company-owned comics set in the DC Universe, such as The Sandman and Hellblazer, and creator-owned works, such as Preacher, Y: The Last Man and Fables.