The 110th Street station is a local station on the IRT Lexington Avenue Line of the New York City Subway. Located in East Harlem at the intersection of 110th Street and Lexington Avenue, it is served by the 6 train at all times, the <6> train during weekdays in the peak direction, and the 4 train during late nights.

The IRT Lexington Avenue Line is one of the lines of the A Division of the New York City Subway, stretching from Lower Manhattan north to 125th Street in East Harlem. The line is served by the 4, ​5, ​6, and <6> trains.