12 East 53rd Street, also the Fisk–Harkness House, is a building in the Midtown Manhattan neighborhood of New York City. It is along the south side of 53rd Street between Madison Avenue and Fifth Avenue. The six-story building was designed by Griffith Thomas and was constructed in 1871. It was redesigned in the Tudor-inspired Gothic Revival style in 1906 by Raleigh C. Gildersleeve.

53rd Street is an east–west street in Midtown Manhattan, New York City, which measures 1.83 miles (2.94 km) long. The street runs westbound from Sutton Place across most of the island's width, ending at DeWitt Clinton Park at Eleventh Avenue.