140–142 Hospital Street, sometimes known as Hospital House, is a substantial townhouse in Nantwich, Cheshire, England, located on the south side of Hospital Street. The building is listed at grade II. It was built in the late 16th century by John Crewe, a tanner, whose sons Randolph and Thomas both served as the Speaker of the House of Commons. The original timber-framed, close-studded façade has been concealed by alterations during the late 17th century; these include the addition of small-paned casement windows, some of which contain old heraldic stained glass. The building was further altered and extended in the 18th century, with the addition of two Gothic-style entrances. Later occupants include the architect, Thomas Bower, and the building remains in residential use.

Nantwich is a market town and civil parish in the unitary authority of Cheshire East in Cheshire, England. It has among the highest concentrations of listed buildings in England, with notably good examples of Tudor and Georgian architecture. It had a population of 14,045 in 2021.