The 16th Street Line, designated Route S2, is a daily bus route operated by the Washington Metropolitan Area Transit Authority between Silver Spring station, which is served by the Red Line of the Washington Metro, and Federal Triangle in Downtown Washington, D.C. with late night and early morning trips extending to L'Enfant Plaza station which is served by the Blue, Orange, Silver, Green and Yellow Lines of the Washington Metro. The line operates every 10 minutes during the weekday peak hours, 15 minutes during the weekday midday and Saturday, 20 minutes on Sunday, and 20 minutes late nights. Trips are roughly 55-60 minutes long.

Silver Spring station is a train station on the Red Line of the Washington Metro and the Brunswick Line of the MARC Train commuter rail system. The Metro station averaged 4,536 daily riders in 2023, making it the 19th-busiest stop in the network and the busiest in the state of Maryland. Trains travelling south from the station quickly cross the border into Washington, D.C., while northbound trains head underground and make their way further into Montgomery County.