The 16th century began with the Julian year 1501 and ended with either the Julian or the Gregorian year 1600 (MDC), depending on the reckoning used.
Mona Lisa, by Leonardo da Vinci, c. 1503–1506, one of the world's best-known paintings
Battle of Cerignola: El Gran Capitan finds the corpse of Louis d'Armagnac, Duke of Nemours
Europe at the time of the accession of Charles V in 1519
Ferdinand Magellan led the first expedition that circumnavigated the globe in 1519–1522.
The Greater Antilles is a grouping of the larger islands in the Caribbean Sea, including Cuba, Hispaniola, Puerto Rico, Jamaica, Navassa Island, and the Cayman Islands. Six island states share the region of the Greater Antilles, with Haiti and the Dominican Republic sharing the island of Hispaniola. Together with the Lesser Antilles, they make up the Antilles, which along with the Lucayan Archipelago, form the West Indies.
Havana Cathedral, built by the Spanish in Cuba between 1748 and 1777
Puerto Rico’s historic district, Old San Juan, contains 16th-century architecture, including the Fort San Felipe del Morro, the Fort San Cristóbal, the City Wall of San Juan, and La Fortaleza.
Citadelle Laferrière, 19th-century fortress in Haiti. It was built by freed slaves as a defence against France
Punta Cana, Dominican Republic
