On 18 July 1806, approximately 40,000 lb (18,000 kg) of gunpowder stored in a magazine (polverista) in Birgu, Malta, accidentally detonated. The explosion killed approximately 200 people, including British and Maltese military personnel, and Maltese civilians from Birgu. Parts of the city's fortifications, some naval stores, and many houses were destroyed. The accident was found to be the result of negligence while transferring shells from the magazine.

Birgu, also known by its title Città Vittoriosa, is an old fortified city on the south side of the Grand Harbour in the South Eastern Region of Malta. The city occupies a promontory of land with Fort Saint Angelo at its head and the city of Cospicua at its base. Birgu is ideally situated for safe anchorage, and over time it has developed a very long history with maritime, mercantile and military activities.