The 182nd Infantry Regiment is a regiment of the United States Army, forming part of the Massachusetts National Guard. It is among the oldest regiments in the U.S. Army, tracing its organizational roots back to 1636, and is one of several National Guard units with colonial roots and a campaign credit for the War of 1812.

The Massachusetts National Guard is the National Guard component for the Commonwealth of Massachusetts. Founded as the Massachusetts Bay Colonial Militia on December 13, 1636, it contains the oldest units in the United States Army. What is today's Massachusetts National Guard evolved through many different forms. Originally founded as a defensive militia for Puritan colonists in the Massachusetts Bay Colony, the militia evolved into a highly organized and armed fighting force. The Massachusetts militia served as a central organ of the New England revolutionary fighting force during the early American Revolution and a major component in the Continental Army under George Washington.