The 1868 United States presidential election in Ohio was held on November 3, 1868, as part of the 1868 United States presidential election. State voters chose 21 electors to the Electoral College, who voted for president and vice president.

The 1868 United States presidential election was the 21st quadrennial presidential election, held on Tuesday, November 3, 1868. In the first election of the Reconstruction Era, Republican nominee Ulysses S. Grant defeated Horatio Seymour of the Democratic Party. It was the first presidential election to take place after the conclusion of the American Civil War and the abolition of slavery. It was the first election in which African Americans could vote in the reconstructed Southern states, in accordance with the First Reconstruction Act.