The 1880–81 Home Nations rugby union matches were a series of international rugby union friendlies held between the England, Ireland, Scotland and Wales national rugby union teams. This season is most notable for the introduction of Wales as an international rugby union nation, playing their first ever match in a game against England. Although Wales were humiliated by a crushing defeat it did not stop rugby union being adopted by Wales as the country's national sport.

The Wales national rugby union team represents the Welsh Rugby Union in men's international rugby union. Its governing body, the Welsh Rugby Union (WRU), was established in 1881, the same year that Wales played their first international against England. The team plays its home matches at the Millennium Stadium in Cardiff, which replaced Cardiff Arms Park as the national stadium of Wales in 1999.