The 1880–81 Scottish Cup – officially the Scottish Football Association Challenge Cup – was the eighth season of Scotland's most prestigious football knockout competition. Defending champions Queen's Park retained the cup and won the competition for the fifth time after they beat Dumbarton 3–1 in a replayed final which saw Dr John Smith score the first Scottish Cup final hat-trick on 9 April 1881.

Dumbarton Football Club is a semi-professional football club in Dumbarton, Scotland. Founded on 23 December 1872, they are one of the oldest football clubs in Scotland.