The 1880 Buffalo Bisons finished the season with a 24–58 record, good for seventh place in the National League.

The original Buffalo Bisons baseball club played in the National League between 1879 and 1885. The Bisons played their games at Riverside Park (1879–1883) and Olympic Park (1884–1885) in Buffalo, New York. The NL Bisons are included in the history of the minor-league team of the same name that still plays today; it is thus the only NL team from the 19th century that both still exists and no longer plays in Major League Baseball.