The 1880 Princeton Tigers football team represented the College of New Jersey, then more commonly known as Princeton College, in the 1880 college football season. The team finished with a 4–0–1 record and was retroactively named co-national champion by the National Championship Foundation and Parke H. Davis. This season was Princeton's tenth national championship and one of 11 in a 13-year period between 1869 and 1881. The captain of the team was Francis Loney.

The Princeton Tigers football program represents Princeton University and competes at the National Collegiate Athletic Association (NCAA) Division I Football Championship Subdivision (FCS) level as a member of the Ivy League. Princeton's football program—along with the football program at nearby Rutgers University—began in 1869 with a contest that is often regarded as the beginnings of American football.